
Menthol
Neurosensory stimulation and scalp microcirculation.
Menthol is a bioactive monoterpene that activates TRPM8 receptors in sensory nerve endings, producing its characteristic cooling response. This neurosensory activity is also associated with increased cutaneous microcirculation, supporting local tissue perfusion and the physiological environment surrounding the hair follicle.While menthol is not considered a direct hair-growth active, its effects on sensory signalling, microcirculation and scalp comfort make it a valuable component in formulations designed to support an active, well-balanced scalp environment.
Caffeine
Follicular stimulation and cellular energy support.
Caffeine is a bioactive methylxanthine with the ability to penetrate the hair follicle and interact with cellular processes involved in hair growth. Experimental studies suggest that caffeine can help counteract inhibitory signals within the follicle while supporting cellular metabolism and proliferation in the hair matrix.Its activity has also been associated with prolongation of the anagen, or active growth phase of the hair cycle. In scalp care, caffeine is therefore used to support follicular activity and create favourable conditions for stronger, more resilient hair growth.
Allantoin
Soothing action and barrier support.
Allantoin is a skin-conditioning active valued for its soothing, keratolytic and barrier-supporting properties. It helps soften the stratum corneum and supports the natural renewal of the skin surface, while reducing sensations of irritation and discomfort.In a scalp-cleansing formulation, allantoin helps counterbalance the potential drying effects of cleansing, supporting hydration and barrier integrity. This makes it particularly relevant for maintaining a calm, comfortable and physiologically balanced scalp.
Inulin
Prebiotic support for the scalp microbiome.
Inulin is a plant-derived polysaccharide and prebiotic used in scalp care to support the balance of the skin microbiome. It can serve as a selective nutrient source for beneficial microorganisms, helping maintain a microbial environment associated with healthy scalp function.Its humectant and conditioning properties also contribute to moisture retention and barrier comfort, making inulin particularly valuable in cleansing formulations where effective removal of sebum and impurities should be balanced with preservation of the scalp’s natural protective ecosystem.
“True strength begins with gentleness.”
Assoc. Prof. Zrinjka Paštar, MD, PhD

